8 Isekai Anime with A Non-Human Main Character

THE PYLORI

That Time I Got Reincarnated as a Slime.

Follows the story of Satoru Mikami, who is reincarnated as a slime in a fantasy world with unique abilities.

Overlord

Features Momonga, a player who gets trapped in a virtual MMORPG as his skeletal avatar, leading his guild of NPCs in this new world. 

The Rising of the Shield Hero.

 This anime delves into his struggle against adversity. It confronts themes of betrayal, resilience, and the growth of an unconventional hero. 

Kemono Michi: Rise Up.

Pro-wrestler Genzou Shibata is transported to a fantasy world where he becomes a beastman and refuses to fight humans, opting to open a pet shop instead. 

Re:Zero – Starting Life in Another World.

While Subaru Natsuki is human, there are non-human characters like Beatrice and Puck who play significant roles in the story. 

Saga of Tanya the Evil.

The main character, Tanya Degurechaff, is a ruthless salaryman reborn as a young girl in a world at war, possessing immense magical abilities. 

Made in Abyss.

Riko and Reg, the human and robot duo, embark on a poignant expedition, blending innocence with the grim realities of their world. 

Drifters.

Warriors from different time periods and backgrounds are summoned to a fantasy world to fight in a war between good and evil.